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Great Dane puppies and dogs in Simpsonville, South Carolina

Looking for a Great Dane puppy or dog in Simpsonville, South Carolina? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you Great Dane in cities near Simpsonville, South Carolina Other pups in Simpsonville, South Carolina Search for a Great Dane puppy or dog near you Browse Great Dane puppies and dogs in nearby cities Browse related breeds in Simpsonville, South Carolina Great Dane shelters and rescues in Simpsonville, South Carolina Learn more about adopting a Great Dane puppy or dog

Adopt a Great Dane near you in Simpsonville, South Carolina

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near Simpsonville, South Carolina

These Great Danes are available for adoption close to Simpsonville, South Carolina.
Photo of Groot

Groot

Great Dane

Male, Young
Spartanburg, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Groot: ✔️Lovable ✔️Funny ✔️Good snuggler ✔️Plays fetch ✔️Likes to meet new people ✔️Smushy face ✔️Gets along with most other dogs ✔️Silly ears ✔️80 pounds ✔️Guaranteed to make you laugh Housebroken, crate-trained, up to date on shots, and neutered. Born in November, 2019.

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Nebula

Great Dane

Female
greenville, SC
Size
(when grown) -
Details
Spayed or Neutered,
Story
Meet Nebula!  She is spayed, microchipped, dewormed, and current with all vaccines (as appropriate for her age) and on flea and heartworm prevention. Nebula is currently being fostered in South Carolina.   ADOPT NEBULA!! www.LuckyPupRescueSC.com The adoption fee is $375.00 and we require a vet check and home visit. May 13, 2026, 5:50 pm

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Nixxie

Great Dane

Female, 2 yrs
Williamston, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Spayed or Neutered,
Story
Meet Nixxie, the gentle giant who's ready to steal your heart! 💘 At just 2 years old , this beautiful Fawn Great Dane has all the big puppy loves and leans ♥ She is a owner surrender to due to health reason. Nixxie is the definition of sweet as sugar!. She is a big, cuddly bundle of joy who gets along fabulously with other dogs. She loves to run and play with her new friends on the farm 🌟 Nixxie’s is new to our rescue and settling in great If you would like to meet this sweet girl and make her a part of you family please contact us at Always Room For one More Rescue Williamston SC 🤗 Nixxie has her bags packed and she is ready to make your life complete✨ Nixxie is waiting for the perfect family are solo best friend! Please contact us today .Our adoption process is simple and our fee's are minimal to make the adoption process smooth and stress free so we can help more pups just like Nixxie find forever loving homes. Apply for the pet here: https://tinyurl.com/2tnra3hj

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Photo of Hemi

Hemi

Great Dane

Male, 7 yrs
Williamston, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
Apply for the pet here: https://tinyurl.com/bvp75t4y

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Photo of Cinderella-Rella

Cinderella-Rella

Great Dane

Female, 3 yrs
Williamston, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs experienced adopter, Spayed or Neutered,
Story
Meet Cinderella, a lovely 2-year-old female Great Dane who is ready to step into her forever home! 🌟🐾 Cinderella aka Rella was found as a stray and taken to a local shelter where we pulled her from Rella has a tough fight she was severley emaciated after a slow refeed and lots of love Rella's personality has blossomed into a affection searching confident little lady.Rella is a staff favorite here at the rescue She has came a long way and is now ready for the next chapter full of love and devotion never to have to be alone hungry nor scared ever again Rella has a true Cinderella story she is just waiting to be someone's little princess👑 Rella loves her stuffies <3 If you would like to meet Rella please contact us at Always Room For One More Williamston SC 💖 Our Adoption process is simple and adoption fee's are minimal. Remember, you can meet Cinderella in person to see if she’s the one for you! Times are very flexible to Meet this sweet girl. Let’s make her next chapter the best one yet. Every animal deserves a happy ending. This one starts with you. 🐶 Apply for the pet here: https://tinyurl.com/49fpzr69

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Photo of Jake

Jake

Great Dane

Male, 7 yrs
Williamston, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Apply for the pet here: https://tinyurl.com/3jtznpjm

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Search for a Great Dane puppy or dog

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Simpsonville, South Carolina.

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Great Dane puppies and dogs in nearby cities

Great Dane Puppies near me Great Dane in Anderson, SC Great Dane in Clinton, SC Great Dane in Easley, SC Great Dane in Fountain Inn, SC Great Dane in Gaffney, SC Great Dane in Greenville, SC Great Dane in Greer, SC Great Dane in Laurens, SC Great Dane in Mauldin, SC Great Dane in Spartanburg, SC Great Dane in Union, SC

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Great Dane shelters & rescues in Simpsonville, South Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in Simpsonville, South Carolina. Browse these Great Dane rescues and shelters below.

Here are a few organizations closest to you:

Rescue

21.9 miles

Lucky Pup Rescue SC

greenville, SC 29617

Pet Types: dogs

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Rescue

23.8 miles

Always Room For One More

Williamston, SC 29697

Pet Types: dogs

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Shelter

42.6 miles

Rutherford County Animal Control Services

545 Laurel Hill Dr, Rutherfordton, NC 28139

Pet Types: cats, dogs, farm animals, rabbits, small animals

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Rescue

42.6 miles

Heart of the Foothills Animal Rescue

380 US HWY 221 N, Rutherfordton, NC 28139

Pet Types: cats, dogs

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Rescue

44.6 miles

Clifford's Army Rescue Extravaganza

P.O. Box 370, Earl, NC 28038

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Great Dane puppy or dog?

We've got all the info you need on adopting and caring for a Great Dane puppy. Check out the links below for everything you ever wanted to know about Great Dane puppies and adults.

Great Dane basics

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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