Great Dane Adoption in South Carolina: Great Dane Puppies for Sale in South Carolina

Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

Haggard*

Great Dane

Male, 7 yrs

Anderson, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

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Harley

Great Dane

Female

greenville, SC

Size

(when grown) -

Details

Story

Meet Harley, Harley is a silly, shy puppy with awesome grey eyes and super cool markings! During the day, she's all about the outdoors and loves running around the yard, lounging in the sun with her littermate, Hooch, or napping under the deck. She's also learning to fetch. At night, she enjoys snuggles before bed. This goofy girl gets snoopy-excited when it's suppertime. Since she spent the first four months of her life in the woods, she needs a little extra coxing sometimes, but she is a sweet, soulful pup who will make a loyal companion given time and attention. She is spayed, microchipped, dewormed, and current with all vaccines (as appropriate for her age) and on flea and heartworm prevention. Harley is currently being fostered in South Carolina. ADOPT HARLEY!! www.LuckyPupRescueSC.com The adoption fee is $300.00 and we require a vet check and home visit. March 22, 2025, 6:46 am

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Oreo

Great Dane/Labrador Retriever

Male, 4 mos

Clinton, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

OreoMale Great Dane/Lab MixDOB: 11/21/2024Adoption Fee: $325Are you looking for a BIG puppy filled with lots of love and energy? Well meet Oreo! He is just a puppy, with really big paws, and of course, those beautiful blue eyes that you'll fall in love with. He's a sweet boy He will be getting neutered within the week, and introduced to walking on a leash. All our pets are posted online and we continue to take applications until they are officially adopted. Many times things change and an approved adopter does not adopt the animal so we do maintain a wait list when necessary.All our adoptable animals are spayed or neutered, micro-chipped, dewormed, UTD on age appropriate vaccines & started on Flea Preventatives. All Canines are started on Heartworm Preventatives and if 6 months or older they are tested for Heartworm Disease.WE ARE OPEN for visitors from 12PM - 4PM Tuesday-Saturdays or by APPOINTMENT at other times. We suggest calling prior to visiting our adoption center to ensure the animal you wish to meet is here at our Center (some are in foster care) and still available. If you want to meet an animal that is being fostered an approved application & appointment is required first.ONCE APPROVED WE WILL CALL/EMAIL YOU - APPROVALS CAN TAKE A FEW DAYS** WEEKEND APPLICANTS **WE ARE CLOSED SUNDAY & MONDAY THUS YOU WILL NOT HEAR BEFORE TUESDAYONLY ONE APPLICATION NEEDEDIf interested in more than one pup just put all the names on one application. If you already have an approved application then email us at lchsmanager@gmail.com to tell us which animals you want to apply for.APPLY HERE: https://form.jotform.com/202887123155152

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Nabisco

Great Dane/Labrador Retriever

Male, 4 mos

Clinton, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

NabiscoMale Great Dane/Lab MixDOB: 11/21/2024Adoption Fee: $325Are you looking for a BIG puppy filled with lots of love and energy? Well meet Nabisco! He is just a puppy, with really big paws. He's a sweet boy He will be getting neutered within the week, and introduced to walking on a leash. Come meet him and see if he's the missing piece in your life. All our pets are posted online and we continue to take applications until they are officially adopted. Many times things change and an approved adopter does not adopt the animal so we do maintain a wait list when necessary.All our adoptable animals are spayed or neutered, micro-chipped, dewormed, UTD on age appropriate vaccines & started on Flea Preventatives. All Canines are started on Heartworm Preventatives and if 6 months or older they are tested for Heartworm Disease.WE ARE OPEN for visitors from 12PM - 4PM Tuesday-Saturdays or by APPOINTMENT at other times. We suggest calling prior to visiting our adoption center to ensure the animal you wish to meet is here at our Center (some are in foster care) and still available. If you want to meet an animal that is being fostered an approved application & appointment is required first.ONCE APPROVED WE WILL CALL/EMAIL YOU - APPROVALS CAN TAKE A FEW DAYS** WEEKEND APPLICANTS **WE ARE CLOSED SUNDAY & MONDAY THUS YOU WILL NOT HEAR BEFORE TUESDAYONLY ONE APPLICATION NEEDEDIf interested in more than one pup just put all the names on one application. If you already have an approved application then email us at lchsmanager@gmail.com to tell us which animals you want to apply for.APPLY HERE: https://form.jotform.com/202887123155152

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Pilate & Marco

Great Dane/American Staffordshire Terrier

Male, Adult

Greenville, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Good with cats, Needs experienced adopter, House-trained,

Story

The boys are amazing, goofy, and sweet. They love to be cuddled up as lap babies and often try to steal your bed or couch. They enjoy going to the dog park and playing with toys and bones. Unfortunately, due to relocating and medical issues, we can no longer keep them. Marco is our Staffordshire Bull Terrier, about 3.5 years old. Pilate is our Great Dane, who will turn 5 on May 4th. We would prefer to have them go together, but we are willing to separate them if necessary.

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Hades

Great Dane/Mastiff

Male, Young

Greenville, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Not good with kids, Good with dogs, Good with cats, Needs experienced adopter, House-trained,

Story

Getting neutered on April 10. Hades will be 3 years old in May, I have owned him since he was 4 months old. He is sweet, cuddly, and very energetic. He needs an experienced owner who can handle his size and energy. He knows all basic commands and is kennel trained. He loves all animals and humans but maybe a bit too much. He is reactive but not aggressive. He needs a lot of attention and ways to exert his energy. He is a great dog but does not understand his size. Looking for someone who has the time and space especially a big backyard to meet his needs.

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Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in South Carolina.

$350 in savings for new adopters

PetSmart is offering new adopters a free adoption kit. Just show your adoption paperwork in-store to redeem!

PetSmart is offering new adopters a free adoption kit. Just show your adoption paperwork in-store to redeem!

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Great Dane puppies and dogs in South Carolina

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Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in South Carolina cities

Great Dane shelters & rescues in South Carolina

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics

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Great Dane puppies and dogs in South Carolina

Jump to:

Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in South Carolina cities

Great Dane shelters & rescues in South Carolina

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics