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Mastiff puppies and dogs in Chillicothe, Ohio

Looking for a Mastiff puppy or dog in Chillicothe, Ohio? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Chillicothe, Ohio Other pups in Chillicothe, Ohio Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Chillicothe, Ohio Mastiff shelters and rescues in Chillicothe, Ohio Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Chillicothe, Ohio

These Mastiffs are available in Chillicothe, Ohio.
We'll also keep you updated on Zara's adoption status with email updates.
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Zara

Mastiff Mutt

Female, Adult
Chillicothe, OH
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Hello meet Zara she is a 5 year old mastiff mix good with other dogs people & children. She is a very lovable girl with lots of energy but loves to jump she loves to be close to you has a little separation anxiety as much as this hurts us to rehome her it is what’s best for our girl &her energy level I am disabled and now have an almost 2 year old little boy that consumes all of my time my husband is a truck driver and drives odd hours so it’s just became alot to accommodate her Zara loves to play and run around we live in the city with a small yard with no fence however she does have an electric fence that can go with her if someone is willing to give her a great home for extra on the adoption fee she just needs someone with land or atleast a fenced in yard & little training she knows how to sit and shake and is cage / crate trained when someone isn’t home and at night please consider welcoming our girl into your family so she can have the life she deserves! ❤️😭

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Or, how about these Mastiffs in cities near Chillicothe, Ohio

These Mastiffs are available for adoption close to Chillicothe, Ohio.
We'll also keep you updated on Zara's adoption status with email updates.
Photo of Zara

Zara

Mastiff Mutt

Female, Adult
Chillicothe, OH
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Hello meet Zara she is a 5 year old mastiff mix good with other dogs people & children. She is a very lovable girl with lots of energy but loves to jump she loves to be close to you has a little separation anxiety as much as this hurts us to rehome her it is what’s best for our girl &her energy level I am disabled and now have an almost 2 year old little boy that consumes all of my time my husband is a truck driver and drives odd hours so it’s just became alot to accommodate her Zara loves to play and run around we live in the city with a small yard with no fence however she does have an electric fence that can go with her if someone is willing to give her a great home for extra on the adoption fee she just needs someone with land or atleast a fenced in yard & little training she knows how to sit and shake and is cage / crate trained when someone isn’t home and at night please consider welcoming our girl into your family so she can have the life she deserves! ❤️😭

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We'll also keep you updated on Mortisha's adoption status with email updates.
Photo of Mortisha

Mortisha

Mastiff Great Dane

Female, 4 yrs 11 mos
Hillsboro, OH
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
🖤🐾 Meet Mortisha 🐾🖤Big girl. Bigger heart. Slightly oversized paws that may gently smack you during play. 😉Mortisha is a stunning Great Dane/Mastiff mix, around 4 years old and 75 lbs (she’s working on gaining about 15 more pounds—snack donations welcome 🍪). She’s spayed, fully vaccinated, heartworm negative, and on flea, tick & heartworm preventatives. She did test positive for Lyme, but don’t worry—she’s being treated and feeling good! Her adoption fee is $225.🐶 She’s met large and small dogs and does well, though she can play a little rough and likes to “smack” with her paws like a clumsy boxer 🥊—a quick “easy” and she settles right down.🐱 Cats? She’s met two and gave them the ultimate insult… total indifference.🍖 Treat motivated, knows sit and shake, and is house trained with zero accidents.🏠 Crates quietly at bedtime, loves blankets for maximum snuggle mode, and is picky about toys (she knows what she likes).🚶‍♀️ Walks nicely after a brief reminder not to pull.🚗 LOVES car rides and insists on the passenger seat—bonus points if the ride includes a drive-thru treat stop (Marathon is her favorite 😏).🍽️ No food aggression noticed, though she’s fed separately.⚠️ Important note: Mortisha can climb out of fencing, so secure fencing or supervised outdoor time is a must.💖 Mortisha is a loving, goofy, blanket-stealing big girl looking for a home that understands large breeds and is ready for cuddles, laughs, and the occasional paw smack.📩 Interested in adopting Mortisha? Message Highland Humane Society to learn more!Mortisha's adoption fee is $225, You can apply on our website www.highlandhumanesociety.org OR stop into the shelter 12- 5 pm Tuesday through Friday or 11 am to 3 pm on Saturday to meet who is available at that time. Please arrive no later than 30 minutes before we close to ensure we have time to do the adoption.Worried about whether she will be a good fit for your home? No worries, we have that covered too! You have up to 2 weeks after adoption to return her for a full refund on your adoption fee.

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We'll also keep you updated on Leo's adoption status with email updates.
Photo of Leo

Leo

Mastiff Rhodesian Ridgeback

Male, Young
Columbus, OH
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Leo is a Mastiff–Ridgeback-Pittbull mix with a heart of gold. Found as a stray and nursed back to health, he’s grown into a loving, intelligent, and loyal companion. He adores other dogs, loves cuddles, and is fully house-trained. Leo is an adventurous soul who thrives in nature, enjoys camping, and has a playful, goofy personality—plus rare double dewclaws that make him extra special. He can be hesitant with new people and has shown reactivity when nervous, so he needs a patient, experienced owner who understands large breeds. Once he trusts you, he becomes the sweetest, most affectionate lap dog you’ll ever meet. Leo would do best on a farm or in a home with plenty of space to explore, play, and feel secure. He’s truly one of a kind and deserves a forever family who will love him as deeply as he loves them.

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Chillicothe, Ohio.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Chillicothe, Ohio

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Mastiff shelters & rescues in Chillicothe, Ohio

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Chillicothe, Ohio. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

33.5 miles

Highland Humane Society

9331 State Route 124, Hillsboro, OH 45133

Pet Types: cats, dogs

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If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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