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Mastiff puppies and dogs in Saint Louis, Missouri

Looking for a Mastiff puppy or dog in Saint Louis, Missouri? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Saint Louis, Missouri

These Mastiffs are available in Saint Louis, Missouri.
We'll also keep you updated on Valentino's adoption status with email updates.
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Valentino

Mastiff Labrador Retriever

Male, 6 mos
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Are you looking for a life-long love? I'm sure to make your heart skip a beat with these longing eyes! Hey there, I'm Valentino! I've had a rough start in life as my owners moved and decided to leave my brother and I behind. We don't let it bother us as we know we will find our forever homes soon. We look to be a mix of Mastiff/Lab but the shelter isn't sure. Will you paw-lease adopt me?  If you're interested in adopting me, fill out an adoption application online at www.polkcountyhumanesociety.org/adopt where you will also find a link to reserve me for an appointment. Some pets are in foster homes or may already have an appointment scheduled, so the appointment is important to make sure I will be available to meet you when you come. Polk County Humane Society is located in Bolivar, Missouri, but also makes transports to the Denver, CO, Des Moines, IA and St. Louis areas twice monthly. For potential adopters in those areas, we can do a virtual visit using FaceTime or another app. Just request an appointment using the same link, but note that you want the visit to be virtual. We will call you at the time of the visit once it is confirmed. For long distance transports to Colorado and Iowa, there is an additional $100 fee to cover the cost of the transport ($65) and a health certificate from a veterinarian ($35). For transports to St. Louis, the additional fee is $50 to help cover gas. Going that last mile home for our sweet pets! All of our pets are neutered or spayed, have vaccinations appropriate for their age, treated with flea/tick/heartworm prevention, dewormed and dogs are also microchipped. #adoptdontshop ##2287925##
We'll also keep you updated on Romeo's adoption status with email updates.
Photo of Romeo

Romeo

Mastiff Labrador Retriever

Male, 6 mos
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Are you looking for a life-long love? I'm sure to make your heart skip a beat with these longing eyes! Hey there, I'm Romeo! I've had a rough start in life as my owners moved and decided to leave my brother and I behind. We don't let it bother us as we know we will find our forever homes soon. We look to be a mix of Mastiff/Lab but the shelter isn't sure. Will you paw-lease adopt me?  If you're interested in adopting me, fill out an adoption application online at www.polkcountyhumanesociety.org/adopt where you will also find a link to reserve me for an appointment. Some pets are in foster homes or may already have an appointment scheduled, so the appointment is important to make sure I will be available to meet you when you come. Polk County Humane Society is located in Bolivar, Missouri, but also makes transports to the Denver, CO, Des Moines, IA and St. Louis areas twice monthly. For potential adopters in those areas, we can do a virtual visit using FaceTime or another app. Just request an appointment using the same link, but note that you want the visit to be virtual. We will call you at the time of the visit once it is confirmed. For long distance transports to Colorado and Iowa, there is an additional $100 fee to cover the cost of the transport ($65) and a health certificate from a veterinarian ($35). For transports to St. Louis, the additional fee is $50 to help cover gas. Going that last mile home for our sweet pets! All of our pets are neutered or spayed, have vaccinations appropriate for their age, treated with flea/tick/heartworm prevention, dewormed and dogs are also microchipped. #adoptdontshop ##2287932##
We'll also keep you updated on Rosie's adoption status with email updates.
Photo of Rosie

Rosie

Mastiff

Female, Young
Webster Groves, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with kids, Not good with dogs, Good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Rosie was found tied to post behind an abandoned building. Suspected to be used in dog fighting. I fell in love with her the moment I met her. Brought my son and my dog to meet her and they all got along great. However, Rosie began to attach herself to me and attacked our dog twice, but gets along fine with my boyfriends dog - they play a lot! She has snarled at son. We have been working on her reactivity. However, I am nervous with her around my son. She is so sweet and cuddly - she thinks she is a lap dog. However, she will defend no matter what and this makes me very nervous. We are starting muzzle training but she can’t be in a muzzle 24/7 and I’m nervous about her snarling at my son. She is great with cats needs- I think ideally she would be in a quiet home with no other dogs (tho would probably enjoy play with a muzzle on) and probably no kids. She is on high alert and very guarding of her people - she love her people so so much
We'll also keep you updated on LILLY's adoption status with email updates.
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Photo of LILLY

LILLY

Mastiff

Female, 3 yrs
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
-
We'll also keep you updated on Bellatrix aka "Willow Eliza"'s adoption status with email updates.
Photo of Bellatrix aka "Willow Eliza"

Bellatrix aka "Willow Eliza"

Mastiff

Female, 7 yrs 3 mos
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Bella is big and beautiful with a personality to match. This six-year-old mastiff mix girl adores people, snuggles, pets, and attention. She is spayed and up-to-date on all her medical care and is heartworm-negative. Bella is a big girl, approximately 65 pounds, so while she is very good with people, she would be best with older kids who can keep up with her size. She is house-trained, and a fenced yard would be best since Bella is a large dog and likes to play. Bella likes her people so much she doesn't want to share and would do best as the only dog in her home. To meet Bella, visit istodaymydayrescue.org to fill out an application. Her adoption fee is $100.
We'll also keep you updated on Marvel's adoption status with email updates.
Photo of Marvel

Marvel

Mastiff

Male, 3 yrs 5 mos
St. Louis, MO
Size
(when grown) -
Details
-
Story
Meet Marvel, Your New Best Friend! Marvel is a 3 year old Mastiff mix who is looking for his furever home. He is a gentle giant who was found wandering during a thunderstorm, seeking safety and comfort. While we don't know much about where Marvel came from, we do know that he arrived with a heart of gold and a massive smile that is sure to melt your heart. Marvel loves to play with other dogs and is always down for snuggles and a good chew toy, making him the perfect cuddle buddy after a long day. Marvel is crate trained and housebroken. He knows basic commands, but can get a little excited when meeting someone new-he might just jump up for a hug! His friendly nature makes every introduction a joyful occasion. Marvel loves to go for walks and is good in the car. He gets along great with other dogs and even smaller animals like cats and chickens! He's always ready to make new friends and share his love with everyone.

Or, how about these Mastiffs in cities near Saint Louis, Missouri

These Mastiffs are available for adoption close to Saint Louis, Missouri.
We'll also keep you updated on Serena's adoption status with email updates.
Photo of Serena

Serena

Mastiff

Female, Puppy
Fenton, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats,
Story
Serena(Williams) was born on 11/17/24. She is going to be a good sized girl considering her dad is a mastiff mix, and momma is a country mutt! She LOVES to play! She would love to have another playful pup in the house! She is getting spayed on 2/4, but can be spoken for before then.January 22, 2025, 12:50 pm
We'll also keep you updated on Shaq's adoption status with email updates.
Photo of Shaq

Shaq

Mastiff

Male, Puppy
Fenton, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats,
Story
Shaq(O’Neal) was born on 11/17/24. His dad is a mastiff mix, and mom is a country mutt. He will be a good sized boy! He absolutely LOVES to play with his sister, so it would be great if he could have another playful pup friend in his new home. He is getting neutered on 2/4, but can be spoken for before then. January 22, 2025, 1:12 pm
We'll also keep you updated on Daisy's adoption status with email updates.
Photo of Daisy

Daisy

Mastiff Terrier (Unknown Type, Medium)

Female, Young
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered, Shots are up-to-date,
Story
Meet Daisy!Daisy is a 1-year-old, 65-pound Mastiff mix with a heart as big as her paws! Rescued as a stray in poor condition, Daisy has been thriving in her foster home and steadily gaining weight. She’s blossomed into a sweet, loving girl who adores bedtime cuddles and following her humans everywhere—they’ll never be alone with her around!Still a playful pup, Daisy has plenty of energy and is house trained and still learning the ropes of training like not jumping on you in excitement. She’s a smart cookie and eager to please, so with patience and consistency, she’ll become an amazing companion. Daisy loves playing with bigger, higher-energy dogs, like her foster family’s huskies, and has shown promise around cats. While she’s still learning to respect feline boundaries, she’s making great progress.Watching Daisy discover toys and grow into her happy, playful self is nothing short of heartwarming. She’s ready to bring her big heart and loyal spirit into a forever home that will love her unconditionally. Could Daisy be your perfect match?IMPORTANT: Please read all below, especially if you live outside of Texas, which is where our rescue is located.Apply to adopt on our website: https://www.charmingpetrescue.org/adoptAll of our animals are spayed/neutered, microchipped, and up to date on shots.ALL of our animals are located in Boerne, TX, but transport after adoption is available to other states for a $300 fee for dogs or an additional fee varying by location for cats. If you are seeing our pets posted in your state, that's because you live near a transport stop, they are not currently at that location. Petfinder lists our pets as 'Out of Town' pets at other locations, and Adopt-a-Pet lists our location as a Transport stop. Those are currently the only options they offer to make this clear, so we put this description we've put at the bottom to explain it. You can read more about transport here: www.charmingpetrescue.org/transportWe understand transport is not an option for everyone, but we offer it at the cost we pay the transport company for those who wish to adopt from us.January 7, 2025, 9:13 pm
We'll also keep you updated on Hammy Bean's adoption status with email updates.
Photo of Hammy Bean

Hammy Bean

Mastiff Mixed Breed (Medium)

Male, 2 yrs 1 mo
Belleville, IL
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Spayed or Neutered,
Story
Hammy Bean, or just "Hammy" to his friends, is an energetic young guy with a big heart and an even bigger personality! This playful pup is always ready to bring the fun, whether it’s zooming around the yard, showing off his goofy antics, or charming you with his sweet, silly grin. Hammy’s love language? Snacks! Treats are the way to his heart, and he’ll happily show off his best tricks for a tasty reward. With his boundless energy and lovable spirit, Hammy would be the perfect match for an active family who’s ready to keep up with his playful nature. If you’re looking for a goofy, snack-obsessed buddy to keep you smiling, Hammy Bean is ready to be your new best friend! Come meet him and see just how big his heart (and his head) really are!
We'll also keep you updated on BALOO's adoption status with email updates.
Photo of BALOO

BALOO

Mastiff

Male, 3 yrs 2 mos
St. Peters, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
Meet Baloo, a 3-year-old Mastiff found in Wentzville on 12/2/24. This goofy, happy boy weighs 85 pounds and could use a little more weight. Baloo has a moderate energy level and shows mild interest in toys. He tolerates ear rubs. Baloo loves attention and greets people by pawing at them. If you`re looking for a big-hearted companion with a playful spirit, Baloo might just be your perfect match! #AdoptBaloo #MastiffLove #GoofyDog #ForeverHomeNeeded

These pups are in Saint Louis, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Louis, Missouri. To see more adoptable Mastiffs in Saint Louis, Missouri, use the search tool below to enter specific criteria!
We'll also keep you updated on Mae's adoption status with email updates.
Photo of Mae

Mae

Bullmastiff

Female, Adult
St Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
BASICS: Bullmastiff / female / 4 years old CHILDREN: Yes, older than 5 due to size CATS: Unknown DOGS: Male dogs over 30lbs, with slow introduction and supervision PERSONALITY: Medium energy level; Very sweet and affectionate; Enjoys taking naps in the sun or on the couch, exploring outdoors in the yard, walking the neighborhood and LOVES hanging out with people. Loves men! TRAINING: Housebroken, leash trained, knows basic obedience and how to use a dog door SPECIAL NEEDS: None VETTING: Fully vaccinated, spayed, microchipped Ready to give Mae the forever home of her dreams? Fill out our Adoption Application, located The Bullpen Way Station & Sanctuary under the 'work with us' tab. We highly recommend that our potential adopters fill out an online application as soon as possible, as it greatly expedites the process of finding the right dog for your situation. Our dogs are available for adoption nationwide but preference is given to adopters willing to do an in-person meeting. Please understand that our dogs are not adopted on a first-come, first-served basis, but rather we strive for a "perfect placement" so we know that they will not be failed again.
We'll also keep you updated on BONE's adoption status with email updates.
Photo of BONE

BONE

Bullmastiff

Male, 2 yrs
St. Louis, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
-

Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Saint Louis, Missouri.

Mastiff puppies and dogs in nearby cities

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Related breeds in Saint Louis, Missouri

Mastiff shelters & rescues in Saint Louis, Missouri

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Saint Louis, Missouri. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

1.8 miles

Polk County Humane Society - St. Louis Transport

10900 Sunset Hills Plaza, St. Louis, MO 63127

Pet Types: cats, dogs

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Shelter

4.8 miles

Animal Protective Association of Missouri

1705 South Hanley Road, St. Louis, MO 63144

Pet Types: cats, dogs, rabbits, small animals

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Rescue

5.4 miles

4 Paws 4 Rescue

Fenton, MO 63026

Pet Types: cats, dogs, rabbits, small animals

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Rescue

6.4 miles

Is Today My Day Rescue

St. Louis, MO 63139

Pet Types: dogs

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Rescue

8.9 miles

Nala and Friends Dog Rescue - ST. LOUIS transport

St. Louis, MO 63118

Pet Types: dogs

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Shelter

10.6 miles

CARE STL

2700 Walnut Place, St. Louis, MO 63103

Pet Types: cats, birds, dogs, farm animals, rabbits, small animals

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Rescue

16.4 miles

Charming Pet Rescue - MO Transport Stop

St. Louis, MO 63303

Pet Types: dogs

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Shelter

20.3 miles

Belleville Area Humane Society

1301 S. 11th St., Belleville, IL 62223

Pet Types: cats, dogs

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Shelter

20.7 miles

St Charles County Humane Services

4850 Mid Rivers Mall Dr, St. Peters, MO 63376

Pet Types: cats, birds, dogs, rabbits, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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