Mastiff Adoption in Colorado: Mastiff Puppies for Sale in Colorado

Adopt a Mastiff near you in Colorado

Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

ICE CUBE

Mastiff

Male, Adult

Denver, CO

Size

(when grown) -

Details

Story

Meet Ice Cube â&#194&#128&#194&#148 a big guy with a grumpy face and a heart of gold. Heâ&#194&#128&#194&#153s done well with other dogs in the past and just needs slow, respectful introductions. Ice Cube is strong on leash, so we recommend a no-pull harness and an adopter experienced with large dogs. Because of his size and strength, heâ&#194&#128&#194&#153d do best in a home with older kids or kids that are used to dogs of his size.May 19, 2025, 8:44 pm

Learn More

Valentino

Mastiff/Labrador Retriever

Male, 9 mos

Aurora, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Are you looking for a life-long love? I'm sure to make your heart skip a beat with these longing eyes! Hey there, I'm Valentino! I've had a rough start in life as my owners moved and decided to leave my brother and I behind. We don't let it bother us as we know we will find our forever homes soon. We look to be a mix of Mastiff/Lab but the shelter isn't sure. Will you paw-lease adopt me? If you're interested in adopting me, fill out an adoption application online at www.polkcountyhumanesociety.org/adopt where you will also find a link to reserve me for an appointment. Some pets are in foster homes or may already have an appointment scheduled, so the appointment is important to make sure I will be available to meet you when you come. Polk County Humane Society is located in Bolivar, Missouri, but also makes transports to the Denver, CO, Des Moines, IA and St. Louis areas twice monthly. For potential adopters in those areas, we can do a virtual visit using FaceTime or another app. Just request an appointment using the same link, but note that you want the visit to be virtual. We will call you at the time of the visit once it is confirmed. For long distance transports to Colorado and Iowa, there is an additional $100 fee to cover the cost of the transport ($65) and a health certificate from a veterinarian ($35). For transports to St. Louis, the additional fee is $50 to help cover gas. Going that last mile home for our sweet pets! All of our pets are neutered or spayed, have vaccinations appropriate for their age, treated with flea/tick/heartworm prevention, dewormed and dogs are also microchipped. #adoptdontshop ##2287925##

Learn More

Clyde(sdale)

Mastiff/Great Dane

Male, 11 mos

Denver, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs,

Story

Drool is Cool!!! Clyde is an adorable giant who is as sweet as he is big. Not really sure of his mix so best guess mastiff/Great Dane. He could totally be a pittie chihuahua but either way he is awesome!! Clyde is extremely dog and people friendly. He is respectful of the older dogs, gentle with the little puppies and a bull in a china shop with the age appropriate (smaller size) heathens that play with him. Clyde was found as a stray on the reservation and was very skinny. His foster family is working diligently to fatten him up (and he loves all food and treats)!! He did not seem to be familiar with different flooring and likely was never indoors but he is a fan now! He uses the doggie door almost all the time )but has to duck as it isn't for such a tall guy). He is gentle on a leash and knows how to sit and shake. He is a leaner and by that we mean he will lean into you. He loves to be touching but isn't overall needy. We have yet to hear him bark and he does well by himself outside in a kennel. He prefers to be in the house and hang with his people (and has discovered a love for couches and dog beds). When he goes outside he initially has the zoomies and gallops like a gangly colt. After a lap or two around the yard he is ready to chill out. Clyde will likely not be a hiking or running buddy but enjoys a nice stroll. This goofy guy is fostered in Colorado Springs and is ready for his forever life. If drool offends you he isn't your guy (not an all the time thing but definitely after food and water). Clyde is neutered, vaccinated, wormed and microchipped. ##2394098##

Learn More

CODA

Mastiff

Female, Adult

Denver, CO

Size

(when grown) -

Details

Story

Coda is a sweet, gentle giant with a heart full of love. She can be a little nervous around new people at first, but she warms up quickly and soaks up affection once she feels safe. Mellow and easygoing, Coda is a wonderful walking buddy and would thrive in a calm home without small kids, where she can build trust at her own pace.May 19, 2025, 2:24 pm

Learn More

Faith

Mastiff/Labrador Retriever

Female, Young

Bailey, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

This is Faith , she is a purebred Mastador and will be 1 in May. She is really sweet and loves to be outside ! For more information contact me. She does have a few health issues. I am willing to negotiate her cost, if it’s the right fit, my husband and I paid 3500 for her.

Learn More

Barkley

Mastiff

Male

Fort Collins, CO

Size

(when grown) -

Details

Good with kids, Good with dogs, House-trained,

Story

Barkely is a 4 1/2 yr Pittie/Mastiff/Heeler mix & a very handsome good boy. He heartily eats his food and treats. He enjoys a variety of veggies, fruit, yogurt, canned food, bone broth as toppers or in a West Paw Topple cup, and a good bone to chew. He also likes a dab of peanut butter before bed. He's a goober!! He is like a train when it's time to go outside to play. He thinks it's a race to get to his favorite ball. He lives for fetch!! Return? Well, he returns and drops the ball a few feet away. He's still slowly working on return and give/release. He is good on harness/lead to walk. He is a big boy, & is strong. He is a "Velcro" dog. He wants to be near his human & is willing to scale a fence to get to you. Therefore- Barkley requires a 6 ft or higher fence. He can not be left unattended outside until you're positive he can not/will not clear the fence. Barkley needs a stable home life. Love, attention, training, and play are highly encouraged, and another dog is highly encouraged to continue dog behavior/play/training. He is kennel-trained, & potty-trained. Please schedule your meet & greet today! March 12, 2025, 3:36 pm

Learn More

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Colorado.

Adopting a new pet? Get a free first vet visit.

Plan ahead for their first week home—with a free visit at one of Banfield Pet Hospital®’s 1,000+ locations. (Terms apply.)

Get Coupon

Mastiff puppies and dogs in Colorado

Jump to:

Adopt a Mastiff near you in Colorado

Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Colorado cities

Mastiff shelters & rescues in Colorado

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics

Home

Adopt a Dog

Adopt a Mastiff

Colorado

Mastiff puppies and dogs in Colorado

Jump to:

Adopt a Mastiff near you in Colorado

Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Colorado cities

Mastiff shelters & rescues in Colorado

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics