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Mastiff puppies and dogs in San Diego, California

Looking for a Mastiff puppy or dog in San Diego, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in San Diego, California

These Mastiffs are available in San Diego, California.
We'll also keep you updated on Jacques-Merced, CA's adoption status with email updates.
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Jacques-Merced, CA

Mastiff

Male, 1 yr 2 mos
Southern CA, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Location: Merced, CA Handsome hunky boy Jacques is around 11 months old. He was rescued off the streets by a kind elderly lady. No microchip or owner has been found. He is a big boy at 100 lbs and just a bit too much puppy for her to keep him. Jacques is sweet, friendly, a big lump of affection, super loving and great with the 4 yr. old child in the home. He loves car rides and playing in the yard chasing tennis balls. Chew bones are the bestest! He is partially blind in one eye but that doesn't stop him. He has been wonderful with the other dog & puppies that were also rescued off the streets, that are also with the elderly finder. Kitties are unknown. Jacques would make a wonderful addition to any family with his loving disposition. If you think he is the right one for you, email the rescue at: info@savethedals.org for an application
We'll also keep you updated on Moose's adoption status with email updates.
Photo of Moose

Moose

Mastiff

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by a community member. Why this pet is the one for you: Moose is a sweet, affectionate, and loyal male mastiff mix, approximately 6 years old. He is a gentle soul who loves to cuddle and be around people. Moose has a calm demeanor and his affectionate nature makes him an ideal companion for a family looking for a loving and devoted dog. Moose is fully vaccinated, microchipped, neutered and ready to go home! . At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for their new home! Primary Color: Fawn Brindle Secondary Color: White Weight: 99 Age: 6yrs 1mths 2wks
We'll also keep you updated on Chestnut's adoption status with email updates.
Photo of Chestnut

Chestnut

Mastiff

Female, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on December 19, 2024. Why this pet is the one for you:Meet Chestnut! While we are still getting to know this pooch, we cannot deny one thing: they're ready for their next chapter in life! A consistent routine and fun, enriching activities will help them get used to their home and feel like part of the family! If you'd like to learn more about this pup come visit us at the San Diego Campus today! She has already been spayed, microchipped, and is up to date on vaccines! Primary Color: Brindle Weight: 101 Age: 4yrs 0mths 1wks
We'll also keep you updated on Jesse's adoption status with email updates.
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Jesse

Mastiff

Female, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on December 18, 2024. Why this pet is the one for you:Meet Jesse! While we are still getting to know this pooch, we cannot deny one thing: they're ready for their next chapter in life! A consistent routine and fun, enriching activities will help them get used to their home and feel like part of the family! If you'd like to learn more about this pup come visit us at the San Diego Campus today! She's been spayed, microchipped, and is up to date on her vaccinations. Primary Color: Brown Brindle Weight: 67.5 Age: 0yrs 9mths 1wks
We'll also keep you updated on Kida's adoption status with email updates.
Special Needs
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Kida

Mastiff Anatolian Shepherd

Female, Adult
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, Needs special attention, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Kida is a gentle giant and a loving family dog. She 4 yrs old and I have had her since she was a pup. She had one litter herself and then was spayed last year. She gets along great with everyone and loves kids, but she does NOT like new men, she needs a female owner and companion. Kida loves naps, sticks, bones, and SNOW days are her favorite. I am extremely busy with work and as a single parent, she needs more time and attention than I can give.

Or, how about these Mastiffs in cities near San Diego, California

These Mastiffs are available for adoption close to San Diego, California.
We'll also keep you updated on BlackJack's adoption status with email updates.
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BlackJack

Mastiff

Male, 4 yrs 6 mos
Jamul, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
House-trained, Spayed or Neutered, Shots are up-to-date,
Story
BlackJack is a fun, lovable big pup. He loves to play fetch, enjoys wading in water, knows sit, down, stay, and he has the cutest puppy-dog face!
We'll also keep you updated on Freeway's adoption status with email updates.
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Freeway

Mastiff

Female, 2 yrs 2 mos
Encinitas, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Freeway, the gentle soul who deserves a second chance at finding a loving family of her own. Freeway has shown her resilience and loving nature despite facing hardship. Found on the streets of Tijuana with her 5 puppies, Freeway unfortunately lost her little ones. Now, she's ready to embark on a new chapter and fill a home with her sweetness and love. Freeway is very affectionate, getting along well with other dogs and is content to be a couch potato, enjoying quiet moments with her loved ones. If you're ready to offer Freeway the love and security she deserves, she's eagerly waiting to become a cherished member of your family. ##2016011##
We'll also keep you updated on Kali's adoption status with email updates.
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Kali

Mastiff

Female, 5 yrs 7 mos
Ramona, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
*This is a courtesy listing.* Meet Kali! 5-year-old Kali needs a loving new home following the recent passing of her mom. Kali can be reserved when first meeting someone nd takes a bit to warm up, but she is very warm and affectionate when she gains trust in the person. Kali was very loving and devoted to her mom, and with time, she will share her big heart with a new family. She enjoys playing fetch and is good with the 2-year-old granddaughter of her late owner. For the past 5 years, Kali has lived with another dog (Kara, also available for adoption), and they get along very well. They eat alongside each other without issue and share space & attention nicely. Both dogs earn high marks from the care staff where they board. If you are looking for a loving, devoted, and well-behaved companion, Kali may be the one for you! To learn more, please email Sandra at sandraj111207@gmail.com. *Frosted Faces Foundation has not assessed this dog medically or behaviorally.*
We'll also keep you updated on URGENT! SAVE ME's adoption status with email updates.
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Photo of URGENT! SAVE ME

URGENT! SAVE ME

Mastiff

Male, 6 yrs
San Marcos, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Shots are up-to-date,
Story
WE ARE COURTESY POSTING THIS DOG FOR THE MORENO VALLEY ANIMAL SHELTER TO HELP THEM FIND A HOME. The shelter is severely overcrowded and desperately needs help. Dogs are being turned in higher numbers than the shelter can accommodate, therefore many are losing their lives due to lack of cage space. We are helping get the word out of their immediate need. Please save this deserving pooch and clear a kennel for another dog in need today! This beautiful dog is located in the Moreno Valley shelter. Please feel free to reach out to us with questions. Thank you! WALTER aka PRINCE and I am a male, black brindle Mastiff mix. The shelter thinks I am about 6 years old. CITY OF MORENO VALLEY NOTES: Our Pet of the Week is Walter, a six-year-old, male black brindle Mastiff mix. If your family is looking for a larger dog that brings extra comfort, joy, and entertainment to the household, Walter is your boy! He is a big dog with a big heart and an even bigger personality. Walter's a lovable teddy bear that is well-disciplined and good on a leash. Moreno Valley Animal Shelter 14041 Elsworth Street, Moreno Valley, CA 92553 951-413-3790 Adoption hours: Tuesday - Friday 10 am - 5 pm Saturday 10:30 am - 3:30 pm Closed Sunday-Monday & Holidays
We'll also keep you updated on Merlin's adoption status with email updates.
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Photo of Merlin

Merlin

Mastiff

Male, 4 yrs 5 mos
Riverside, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Merlin! He is a 4 year old Mastiff. Merlin was rescued from the shelter over three months ago. He is still healing from a knee surgery so although he's not available for adoption yet we are accepting applications. He is good with people and most dogs. He is a calm playful gentle boy.
We'll also keep you updated on Hannah's adoption status with email updates.
Photo of Hannah

Hannah

Mastiff American Pit Bull Terrier

Female, Adult
Riverside, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
COURTESY POST Hannah’s journey hasn’t been an easy one. She found herself scared and just days away from giving birth at one of California’s toughest high-kill shelters, where she and her 10 puppies were placed on the euthanasia list. But Real Good Rescue and two amazing rescue partners came together to save this brave mama. Despite losing seven of her puppies during this tough transition, Hannah’s spirit never wavered. She proved to be the most loving and dedicated mother, nurturing her babies with unwavering attention, care and play. Thanks to her, all three surviving puppies were quickly adopted into loving homes. And like most mama dogs, Hannah was overlooked. Now, it’s Hannah’s turn to find the forever home she so deeply deserves. At 75lbs and approximately 4 years old, Hannah is the perfect mix of active and chill. She’s a social butterfly who’s lived harmoniously with small dogs and even a 5-year-old child. However, her dream home would be calm, peaceful, and all about her—no other pets, just allowing Hannah to soak up all the love. Outdoors, she enjoys staying active and exploring, but indoors she’s the ultimate couch potato, ready for cuddles and naps. If you or someone you know is ready to give this incredible girl the life and love she’s been waiting for, email adopt@realgood.

These pups are in San Diego, California too!

Below are our newest added Mastiffs available for adoption in San Diego, California. To see more adoptable Mastiffs in San Diego, California, use the search tool below to enter specific criteria!
We'll also keep you updated on Hippo's adoption status with email updates.
Special Needs
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Hippo

Bullmastiff

Male, Adult
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Needs special attention, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Your Gentle Giant Looking for Love! Hello there, I'm Hippo, a 5-year-old Bull Mastiff mix, a big boy at 87 lbs, and neutered. I was pulled from the Riverside shelter by TAP and I am so grateful for that! I have picked up bathroom manners, working on leash manners. I have separation  anxiety and current medications to help with separation anxiety include Trazodone (~$7.00), Gabapentin (~$13.00), Acepromazine as needed (~$25.00), and Prozac (~$5.00). Monthly cost depending on where purchased and market value.  I may look imposing at first glance, but once you get to know me, you'll see I'm the sweetest and most loveable companion you could ever ask for. I love affection, and snuggling up next to my humans is one of my favorite pastimes. I'm generally friendly with other dogs, but I might need a slow introduction to make sure we're all on the same page. When I'm inside the house, I sometimes get a bit anxious and bark at people passing by, but don't worry – once we're outside, I'll mostly be an observer, calmly taking in the world around me. I can show some leash reactivity though. With some patience, understanding, and positive reinforcement training, I'm sure I can overcome this behavior. I adore outdoor adventures and walks, but I can get a little distracted if there's too much going on around me. I find night walks with minimal distractions to be the best for me. That way, I can focus on our quality time together without getting overwhelmed by everything happening around us. One of my quirks is that I like to playfully bite ankles and wrists when I want to wake you up or just engage in some playtime. I promise it's all in good fun! But for this reason, a family with older kids or adults might be a better fit for me. I would absolutely love a fun-loving home with a yard! Having a safe and secure place to play and explore would make me one happy pup! I'm quite adaptable, so whether you lead an active lifestyle or prefer a more laid-back approach, I'll fit right in. Just as long as I get plenty of love and attention, I'll be content. So, are you ready to open your heart and home to a gentle giant like me? I guarantee that with a little understanding, patience, and love, I'll be the most loyal and loving companion you could ever wish for. Let's embark on this incredible journey together, creating unforgettable memories and forging an unbreakable bond. ##1733826##
We'll also keep you updated on Leo's adoption status with email updates.
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Photo of Leo

Leo

Neapolitan Mastiff

Male, Adult
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Leo is a gorgeous neapolitan mastiff.  His ideal home would be a home with someone who knows the breed and can set boundaries for him to thrive. He has the potential to do well with other dogs as long as the other dogs have good temperament. He was fostered with kids who were 12 years of age and he did good with them. Come meet sweet Leo if you are looking for a gorgeous large boy. Leo's adoption comes with training. December 26, 2024, 11:26 pm
We'll also keep you updated on Simba's adoption status with email updates.
Photo of Simba

Simba

St. Bernard Anatolian Shepherd

Male, 4 yrs 4 mos
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
DOB: August 2020Weight: 80 lbsDisposition: Happy, Easy-going, PlayfulFrom: San Bernardino area where he was relegated to the outdoor side yard with his friend (and baby mama and their 4 puppies).Best Attribute (IOHO): EXCELLENT with kids. They can literally walk him.Area for Opportunity: Has a booming bark, especially if someone approaches the fence line.Best Home: Active family looking for a gentle giant that can reliably play and tumble with the kids.If you're interested in meeting this gentle giant, please visit our website to fill out an adoption application, www.thebarkinglot.net/adoptTo initiate the adoption process for this dog, please complete our online application by clicking below. Your adoption coordinator will respod to you via email once they receive your application: www.thebarkinglot.net/adopt

Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in San Diego, California.

Mastiff puppies and dogs in nearby cities

Related breeds in San Diego, California

Mastiff shelters & rescues in San Diego, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in San Diego, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

2.3 miles

Save the Dalmatians and Others Canine Rescue, Inc

San Diego, Orange County, Los Angeles, California, dogs are fostered in So California, Southern CA, CA 92104

Pet Types: dogs

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Shelter

3.6 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

20.7 miles

Rescuing Cujo

PO Box 81, Jamul, CA 91935

Pet Types: dogs

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Rescue

23.8 miles

Tragic To Magic - La Jolla

453 Encinitas Blvd, Encinitas, CA 92024

Pet Types: cats, dogs

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Rescue

27.2 miles

Frosted Faces Foundation

1448 Pine St, Ramona, CA 92065

Pet Types: cats, dogs

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Rescue

29.5 miles

Saving Shelter Pets of CA

San Marcos, CA 92069

Pet Types: dogs

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Rescue

32.8 miles

Underdog Heroes

Riverside, CA 92058

Pet Types: dogs

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Rescue

37.2 miles

The Dank Dog Rescue & Sanctuary

Valley Center, CA 92082

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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