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Great Dane puppies and dogs in Winston Salem, North Carolina

Looking for a Great Dane puppy or dog in Winston Salem, North Carolina? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you Great Dane in cities near Winston Salem, North Carolina Other pups in Winston Salem, North Carolina Search for a Great Dane puppy or dog near you Browse Great Dane puppies and dogs in nearby cities Browse related breeds in Winston Salem, North Carolina Great Dane shelters and rescues in Winston Salem, North Carolina Learn more about adopting a Great Dane puppy or dog

Adopt a Great Dane near you in Winston Salem, North Carolina

These Great Danes are available in Winston Salem, North Carolina.
We'll also keep you updated on Carlton's adoption status with email updates.
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Carlton

German Shepherd Dog Great Dane

Male
Winston-Salem, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
A really nice stray who was never claimed at a high-kill animal control facility, so we rescued him...He's gentle, quiet, and a great companion...Would be a nice family dog. Fenced yard required; VET'S REFERENCE REQUIRED.March 9, 2026, 5:29 pm

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Or, how about these Great Danes in cities near Winston Salem, North Carolina

These Great Danes are available for adoption close to Winston Salem, North Carolina.
We'll also keep you updated on Diesel's adoption status with email updates.
Photo of Diesel

Diesel

Great Dane

Male, Senior
Thomasville, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Diesel is a sweet older Great Dane mix dog.  His vet estimated birth date is 2017.  He weighs 77 pounds.  He'd love taking walks and then coming home to nap at your feet.  He can be a little iffy with other dogs, so he'd probably do best as an only dog, or you would need to do a very slow introduction if you have other dogs.  Diesel walks well on a leash. ~Adoption donation $200 . All vetting is up to date. Microchipped and neutered. Also on flea/tick and heartworm preventative. Visit www.ruffloverescue.com/adoption and fill out an application to make this pup a member of your family March 7, 2026, 6:47 pm

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We'll also keep you updated on Tito's adoption status with email updates.
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Tito

Great Dane

Male, 4 yrs 10 mos
Stokesdale, NC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with kids, Not good with dogs, Not good with cats,
Story
Are you ready to be captured by the charm of a huge dog? Look no further, this is Tito. Tito is a 3-year-old Great Dane looking for his forever home when his previous home did not work out for him. This boy is already housebroken, crate trained and gets along great with other dogs. We are looking for a home for this small horse (approximately 110 lbs.) that has previous giant breed experience and does not have young children in the home. Tito loves car rides, attention and enjoying the finer things in life like a comfortable afternoon nap. If your home is looking for a handsome addition look no further and visit us at reddogfarm.com to fill out an application.

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We'll also keep you updated on Wesley's adoption status with email updates.
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Wesley

Great Dane

Male, 1 yr 4 mos
Salisbury, NC
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Wesley, who comes to us from the Cabarrus County Animal Shelter. Wesley is a 1-year-old, 55 lb., Great Dane mix. He is such a loving boy, good with other dogs, and is extremely affectionate with kids. Wesley is housebroken, crate trained, loves to play, is good on outdoor recall off leash, loves to snuggle, and is overall very well behaved. He shows no signs of aggression. Wesley is neutered, fully vaccinated, microchipped, and is thriving in his foster home. Because he is so good with other dogs, he would do best in a home with other fur siblings. If you would like to meet Wesley, please reach out to us for an application.

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We'll also keep you updated on Xena's adoption status with email updates.
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Xena

Great Dane

Female, 4 yrs 6 mos
Salisbury, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Xena, who comes to us as an owner surrender when her previous owners had a change in their lifestyle where neither were able to keep her. Xena is a 4–5-year-old, 93.5 lb., Great Dane. This gentle giant is a sweet soul who radiates love and affection, craving the company of humans - adults and kids alike - and harmoniously accepts other dogs and cats. Xena is housebroken, crate trained, and food motivated, with a talent for sitting on command, offering her paw, and showering her loved ones with kisses and hugs. With her excellent leash manners, Xena enjoys leisurely strolls, and car rides. Her calm demeanor makes her an ideal companion, whether at home, in the park, or on an adventure. Xena is spayed, current on her vaccinations, and microchipped. Her foster family adores her, and you will too. If you would like to meet Xena, please reach out to us for an application.

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We'll also keep you updated on Chase's adoption status with email updates.
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Chase

Great Dane Mixed Breed (Large)

Male, 2 yrs 5 mos
Martinsville, VA
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Spayed or Neutered,
Story
We advise all adopters to expect the 3-3-3 rule as a general guideline for introducing a pet to the home: 3 days to decompress (will show nervousness, hiding, reduced appetite), 3 weeks to settle into a routine (beginning to explore and showing personality), and 3 months to build trust and feel fully comfortable in their new home. This period may be longer for shy or extremely scared animals. Meet a 2 and 1/2 year old boy who's always ready for his next adventure! He's full of energy, loves to explore, and would thrive with an active family that can keep up with his fun-loving spirit. Despite his playful side he is also incredibly sweet, affectionate, and loves being close to his people. He already knows "sit" and will happily give you his paw like the perfect gentleman. He's smart, eager to engage, and enjoys both playtime and attention. Because he has a very high prey drive he absolutely cannot live with cats or livestock. He will do best in a home that understands his energy level and can provide, structure, exercise, and lots of love.

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We'll also keep you updated on Carlton's adoption status with email updates.
Photo of Carlton

Carlton

German Shepherd Dog Great Dane

Male
Winston-Salem, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
A really nice stray who was never claimed at a high-kill animal control facility, so we rescued him...He's gentle, quiet, and a great companion...Would be a nice family dog. Fenced yard required; VET'S REFERENCE REQUIRED.March 9, 2026, 5:29 pm

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Search for a Great Dane puppy or dog

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Winston Salem, North Carolina.

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Great Dane puppies and dogs in nearby cities

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Great Dane shelters & rescues in Winston Salem, North Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in Winston Salem, North Carolina. Browse these Great Dane rescues and shelters below.

Here are a few organizations closest to you:

Rescue

19.5 miles

Ruff Love Rescue and Foster Care

P. O. Box 2013, Thomasville, NC 27361

Pet Types: cats, dogs

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Rescue

31.1 miles

Faith Hope and Love Animal Rescue NC

PO Box 4463, Salisbury, NC 28145

Pet Types: dogs

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Shelter

48.5 miles

Martinsville Henry County SPCA

132 Joseph Martin Hwy, Martinsville, VA 24112

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Great Dane puppy or dog?

We've got all the info you need on adopting and caring for a Great Dane puppy. Check out the links below for everything you ever wanted to know about Great Dane puppies and adults.

Great Dane basics

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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