Great Dane Adoption in San Francisco, CA: Great Dane Puppies for Sale in San Francisco, CA

Adopt a Great Dane near you in San Francisco, California

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near San Francisco, California

These Great Danes are available for adoption close to San Francisco, California.

GUINNESS

Great Dane Shepherd (Unknown Type)

Male, 5 yrs 1 mo

Pt. Richmond, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Spayed or Neutered,

Story

Who has 4 paws and is a good boy? Guinness!! This guy is looking for his forever family to enjoy life with as much as he does. Its impossible to not smile when you see those big ears and happy face come running to you! Guinness doesn't just love people he loves making new friends with every dog he meets. (No cats for this boy, though!) He is a social butterfly. This boy is happy, loving, energetic, and always ready for a play date or an adventure. Turn in an application today and come get one of Guinness hugs. A volunteer had this to say, "Guinness is a very sweet boy who is not fully aware of his size and strength.He needs a little training to learn not to jump up and/or pull on his leash, but at heart is a goofball gentle giant."

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GRANOLA

Great Dane Anatolian Shepherd

Male, 4 mos

Fairfield, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Spayed or Neutered,

Story

Meet Granola! Granola is a 5-month-old Great Dane mix (with a touch of Anatolian Shepherd) who’s got a big future ahead of him—and he’s looking for the right person to help him grow into it. This gentle giant-in-the-making is searching for a forever home filled with patience, understanding, and lots of love. Right now, Granola is a shy and submissive puppy who is still learning that the world can be a safe and happy place. He shows signs of limited early socialization, which means new experiences can feel overwhelming for him. But beneath that timid exterior is a sweet, sensitive pup who just needs time, guidance, and reassurance to come out of his shell. Because Granola is expected to grow into a very large dog, it’s especially important that his adopter is committed to training, structure, and confidence-building from the start. He may have missed some early developmental experiences, but with consistent positive reinforcement and gentle exposure to new people, places, and situations, he has every chance to become a well-rounded and confident adult. Granola will thrive with someone who understands that progress may be slow at first—but incredibly rewarding. Watching him gain confidence, trust, and joy in everyday life will be a journey worth taking. Granola may be a little unsure right now, but with the right home, he has the potential to grow into a confident, loyal, and loving companion. He’s just waiting for someone to believe in him. Could you be the one to help Granola grow into the amazing dog he’s meant to be?

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TRAIL MIX

Great Dane Anatolian Shepherd

Female, 4 mos

Fairfield, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Spayed or Neutered,

Story

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PRETZEL

Great Dane Anatolian Shepherd

Male, 4 mos

Fairfield, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Spayed or Neutered,

Story

Meet Pretzel! Pretzel is a 5-month-old Great Dane mix (with a touch of Anatolian Shepherd) who’s got a big future ahead of him—and he’s looking for the right person to help him grow into it. This gentle giant-in-the-making is searching for a forever home filled with patience, understanding, and lots of love. Right now, Pretzel is a shy and submissive puppy who is still learning that the world can be a safe and happy place. He shows signs of limited early socialization, which means new experiences can feel overwhelming for him. But beneath that timid exterior is a sweet, sensitive pup who just needs time, guidance, and reassurance to come out of his shell. Because Pretzel is expected to grow into a very large dog, it’s especially important that his adopter is committed to training, structure, and confidence-building from the start. He may have missed some early developmental experiences, but with consistent positive reinforcement and gentle exposure to new people, places, and situations, he has every chance to become a well-rounded and confident adult. Pretzel will thrive with someone who understands that progress may be slow at first—but incredibly rewarding. Watching him gain confidence, trust, and joy in everyday life will be a journey worth taking. Pretzel may be a little unsure right now, but with the right home, he has the potential to grow into a confident, loyal, and loving companion. He’s just waiting for someone to believe in him. Could you be the one to help pretzel grow into the amazing dog he’s meant to be?

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HENRY

Hound (Unknown Type) Great Dane

Male, 2 yrs 5 mos

Pt. Richmond, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered,

Story

Meet Henry - a big ol' goofy lovebug who deserves his happily ever after! Henry has been living the best life in foster for the past few months, where he's totally thrived, with beach adventures, hikes, and plenty of snuggles. Here's what his wonderful foster pawrents have to say: "Henry is good with dogs big and small and has great manners, so will let dogs be if they are not interested in playing. He can be a rough player and loves to wrestle with other big dogs if the other dog encourages it. He would likely not be good around cats. He's great with children, I've seen him around kids as young as 2-3 years old and he's gentle with them. He seems to understand they are human puppies. Henry is what I would describe as a medium energy dog. He is a goofy boy and very affectionate. He is a big boy at about 95lbs. I have been bringing Henry to work with me in a small office and he settles and knows the routine. He can be a little barky when new people come into the space, but he knows my coworkers and is excited to greet them each day. He could also be left at home for the workday. He is fully potty trained, only chews on his toys and he would love it if he was allowed on the couch. He sleeps in our living room and through the night. He does not get into the trash and understands counters and tables are off limits to him. He walks great on leash, especially on routes he goes on regularly. He does have some interest in squirrels, so due to his size, we'd recommend a strong handler. He's great in the car and loves to have his head out the window whenever possible. Henry also LOVES the beach!" If you're interested in offering this darling boy a forever home, apply today to meet him! Henry's adoption fee has kindly been sponsored by a generous donor.

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Lexa

Anatolian Shepherd Great Dane

Female, Adult

Novato, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Meet Lexa, a sweet and gentle Anatolian Shepherd with a shy and independent spirit. Initially nervous around new people, Lexa warms up with patience and gentle interaction, revealing her loving nature. She thrives in a calm environment where she can feel secure and loved. Lexa's ideal home would be with someone who appreciates her gentle soul and respects her space as she adjusts. Adopting Lexa means gaining a loyal and affectionate companion who will enrich your life with her quiet, steadfast presence. Primary Color: Black Brindle Secondary Color: White Weight: 103 Age: 2yrs 4mths 4wks

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These pups are in San Francisco, California too!

Below are our newest added Great Danes available for adoption in San Francisco, California. To see more adoptable Great Danes in San Francisco, California, use the search tool below to enter specific criteria!

Rocky

German Shepherd Dog Anatolian Shepherd

Male, Puppy

San Francisco, CA

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Not good with kids, Needs experienced adopter, House-trained, Shots are up-to-date,

Story

Rocky is a smart, affectionate young pup with a big personality and an even bigger heart. Born on September 30, 2025, he’s at a great age to keep learning and growing with his future family. He loves being around people and builds strong bonds with those he trusts. Rocky is playful, curious, and eager to engage, making him a fun and rewarding companion. He has already started basic training and does best with consistency and gentle guidance. Rocky would thrive in a home that can give him structure, attention, and continued training as he matures. With the right environment, he has all the potential to become a loyal and well-rounded dog. If you’re looking for a loving, energetic pup to grow with, Rocky could be a great fit.

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Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in San Francisco, California.

Great Dane puppies and dogs in San Francisco, California

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Adopt a Great Dane near you in San Francisco, California

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near San Francisco, California

These Great Danes are available for adoption close to San Francisco, California.

These pups are in San Francisco, California too!

Below are our newest added Great Danes available for adoption in San Francisco, California. To see more adoptable Great Danes in San Francisco, California, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in nearby cities

Related breeds in San Francisco, California

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Great Dane basics

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Great Dane puppies and dogs in San Francisco, California

Learn More:

Adopt a Great Dane near you in San Francisco, California

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near San Francisco, California

These Great Danes are available for adoption close to San Francisco, California.

These pups are in San Francisco, California too!

Below are our newest added Great Danes available for adoption in San Francisco, California. To see more adoptable Great Danes in San Francisco, California, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in nearby cities

Related breeds in San Francisco, California

Great Dane shelters & rescues in San Francisco, California

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog?

Great Dane basics

Great Dane basics