When comparing the differences between Great Danes and Irish Wolfhounds, both breeds are impressively large. But a male Irish Wolfhound is at least 32 inches tall (and often taller), while Great Dane males are typically 30 to 32 inches tall. Great Danes tend to weigh more, however, at between 110 and 175 pounds, while Irish Wolfhounds weigh between 105 and 120 pounds. Of course, there is great variation among individual dogs of both breeds as well.