Yes, American Hairless Terriers can be good with cats, but it largely depends on the individual temperaments of the dog and cat. Introducing an American Hairless Terrier to cats from a young age can help them coexist peacefully. However, some American Hairless Terriers have a high prey drive, which can make them more inclined to chase small animals like cats. It’s important to monitor interactions and provide a safe space for the cat to retreat if needed.